Glossary

Platelet-rich fibrin (PRF)

PRF is a platelet concentrate produced without anticoagulant, so the blood clots during centrifugation and forms a fibrin matrix. It is described as a second-generation platelet concentrate and comes in solid and liquid forms.

In practice

Because PRF requires no anticoagulant, timing matters: the blood must reach the centrifuge quickly. This is an operational constraint on room layout, not just on protocol.

See also

Injectable PRF (i-PRF)i-PRF is a liquid form of platelet-rich fibrin prepared at low centrifugal force and short duration, which leaves it injectable before it clots.
Leukocyte- and platelet-rich fibrin (L-PRF)L-PRF is the original solid platelet-rich fibrin, produced by centrifuging blood without anticoagulant so that a fibrin clot forms during the spin.
Advanced PRF (A-PRF)A-PRF is a solid platelet-rich fibrin produced with reduced force and increased time relative to the original L-PRF protocol, with the aim of raising leukocyte content and distributing cells more evenly through the clot.