Glossary

Relative centrifugal force (RCF)

RCF is the force a centrifuge applies to a sample, expressed as a multiple of Earth's gravity and written as g. It is what a spin protocol specifies. RCF depends on both rotor speed and rotor radius, so the same RPM produces different RCF in different machines.

Figure

Force is not one number

AXIS OF ROTATION RCF-MIN 326 g · same spin RCF AT THE CLOT 408 g · same spin RCF-MAX 653 g · same spin One spin. Three different forces. "400 g" is not an answer until you say where.

Figure. Relative centrifugal force grows with distance from the axis, so a single tube experiences a range of forces rather than one value. The original L-PRF protocol is 408 g at the clot, 653 g at the tube bottom, and 326 g at the top. Those three figures describe the same spin.

In practice

RCF is calculated as 1.118 x 10⁻⁵ x r x N², where r is the rotor radius in centimetres and N is speed in RPM. Some manuals write it as 11.18 x r x (N/1000)², which is the same relation. Because force grows with distance from the axis, there is no single RCF in a tube: papers distinguish RCF-max, RCF-min, RCF-average, and RCF at the clot.

See also