--- title: Calcium chloride url: https://regenmedtools.com/glossary/calcium-chloride/ type: glossary primaryQuery: calcium chloride prp activation --- # Calcium chloride Calcium chloride is used to activate platelets in citrate-anticoagulated PRP. Citrate anticoagulants work by binding calcium, so adding calcium back restores the clotting cascade and triggers platelets to release their growth factors. Whether a protocol activates before injection, and with what, is a real fork in the product. ## Related - [platelet-activation](https://regenmedtools.com/glossary/platelet-activation/) - [sodium-citrate](https://regenmedtools.com/glossary/sodium-citrate/)